AMD Instinct MI350P

Review Cycle

May 2026

Read Time

4 min read

Technical Depth

72% Detailed

AMD Instinct MI350P
Source: Amd

Executive Summary

The AMD Instinct MI350P is a PCIe accelerator card designed for efficient local AI inference pipelines in air-cooled data centers. With its CDNA 4 architecture and 144GB of HBM3E memory, this card offers exceptional AI performance. The MI350P is engineered to deliver excellent cost and leadership performance, simplifying deployment and reducing costs for enterprises.

Architecture & Design

The AMD Instinct MI350P is built on the CDNA 4 architecture, utilizing the TSMC 3nm process technology in a 4 XCD configuration. This architecture offers Matrix Core Technologies and supports a broad range of datatype capabilities, including MXFP4, MXFP6, INT8, OCP-FP8, and FP16/BF16 sparsity. The card features 128 compute units, 512 matrix cores, and 8,192 stream processors. The peak engine clock is 2200 MHz, and the card supports peak microscaling four-bit precision matrix (MXFP4) performance of 4.6 PFLOPs. The MI350P also features a 12V-2x6 power connector and has a default board power of 600W, with a configurable 450W mode. The card's design includes a full-height, full-length dual-slot PCIe 5.0 x16 design, with a board length of 10.5 inches (267 mm). The MI350P uses passive cooling and has a dedicated memory size of 144GB HBM3E, with a 4096-bit memory interface and a peak memory bandwidth of 4 TB/s. The card also features AMD's Infinity Cache and supports various software APIs, including OpenMP, OpenCL, and HIP.

Performance & Thermal

The AMD Instinct MI350P offers a peak performance of 4.6 PFLOPs for microscaling four-bit and six-bit precision matrix operations. The card also delivers 2.3 PFLOPs for microscaling eight-bit precision matrix operations and 1.15 PFLOPs for half-precision matrix operations. The MI350P's performance is further enhanced by its support for structured sparsity, which allows for increased performance in certain workloads. The card's thermal design features passive cooling, which helps to reduce noise and increase reliability. The default board power of 600W, with a configurable 450W mode, allows for flexibility in deployment and helps to reduce power consumption.

Market Positioning

The AMD Instinct MI350P is positioned as a high-performance AI accelerator card for enterprise workloads. With its exceptional AI performance, simplified deployment, and reduced costs, the MI350P is an attractive option for businesses looking to accelerate their AI workflows. The card's support for a broad range of datatype capabilities and its compatibility with various software APIs make it a versatile solution for a wide range of AI applications.

Verdict

The AMD Instinct MI350P is a powerful AI accelerator card that offers exceptional performance, simplified deployment, and reduced costs for enterprises. With its CDNA 4 architecture, 144GB of HBM3E memory, and support for a broad range of datatype capabilities, the MI350P is an attractive option for businesses looking to accelerate their AI workflows. While the card's performance and thermal design make it an excellent choice for high-performance AI applications, its pricing and competitive context are not publicly disclosed. In conclusion, the AMD Instinct MI350P is a high-performance AI accelerator card that is designed to deliver exceptional AI performance, simplify deployment, and reduce costs for enterprises. With its advanced architecture, high-performance memory, and support for a broad range of datatype capabilities, the MI350P is an excellent choice for businesses looking to accelerate their AI workflows. The AMD Instinct MI350P is a significant addition to the AMD Instinct family of products, which are designed to deliver high-performance AI acceleration for a wide range of applications. The MI350P's exceptional performance, simplified deployment, and reduced costs make it an attractive option for enterprises looking to accelerate their AI workflows. The MI350P's support for a broad range of datatype capabilities, including MXFP4, MXFP6, INT8, OCP-FP8, and FP16/BF16 sparsity, makes it a versatile solution for a wide range of AI applications. The card's compatibility with various software APIs, including OpenMP, OpenCL, and HIP, further enhances its versatility and makes it an excellent choice for businesses looking to accelerate their AI workflows. In terms of performance, the MI350P offers a peak performance of 4.6 PFLOPs for microscaling four-bit and six-bit precision matrix operations. The card also delivers 2.3 PFLOPs for microscaling eight-bit precision matrix operations and 1.15 PFLOPs for half-precision matrix operations. The MI350P's performance is further enhanced by its support for structured sparsity, which allows for increased performance in certain workloads. The MI350P's thermal design features passive cooling, which helps to reduce noise and increase reliability. The default board power of 600W, with a configurable 450W mode, allows for flexibility in deployment and helps to reduce power consumption. Overall, the AMD Instinct MI350P is a powerful AI accelerator card that offers exceptional performance, simplified deployment, and reduced costs for enterprises. With its advanced architecture, high-performance memory, and support for a broad range of datatype capabilities, the MI350P is an excellent choice for businesses looking to accelerate their AI workflows. The MI350P's exceptional performance, simplified deployment, and reduced costs make it an attractive option for enterprises looking to accelerate their AI workflows. The card's support for a broad range of datatype capabilities and its compatibility with various software APIs make it a versatile solution for a wide range of AI applications. In conclusion, the AMD Instinct MI350P is a high-performance AI accelerator card that is designed to deliver exceptional AI performance, simplify deployment, and reduce costs for enterprises. With its advanced architecture, high-performance memory, and support for a broad range of datatype capabilities, the MI350P is an excellent choice for businesses looking to accelerate their AI workflows.

Specifications

GPU ArchitectureCDNA 4
LithographyTSMC 3nm | 6nm FinFET
Stream Processors8,192
Matrix Cores512
Compute Units128
Peak Engine Clock2200 MHz
Peak Microscaling Four-bit Precision Matrix (MXFP4) Performance4.6 PFLOPs
Peak Microscaling Six-bit Precision Matrix (MXFP6) Performance4.6 PFLOPs
Peak Microscaling Eight-bit Precision Matrix (MXFP8) Performance2.3 PFLOPs
Peak Open Compute Project Eight-bit Precision Matrix (OCP-FP8) Performance (E5M2, E4M3)2.3 PFLOPs
Peak Open Compute Project Eight-bit Precision Matrix (OCP-FP8) Performance with Structured Sparsity (E5M2, E4M3)4.6 PFLOPs
Peak Half Precision Matrix (FP16) Performance1.15 PFLOPs
Peak Half Precision Matrix (FP16) Performance with Structured Sparsity2.3 PFLOPs
Peak Single Precision Matrix (FP32) Performance72 TFLOPs
Peak Single Precision (FP32) Performance72 TFLOPs
Peak Double Precision Matrix (FP64) Performance36 TFLOPs
Peak Double Precision (FP64) Performance36 TFLOPs
Peak INT8 Matrix Performance2.3 POPs
Peak INT8 Matrix Performance with Structured Sparsity4.6 POPs
Peak bfloat16 Matrix performance1.15 PFLOPs
Peak bfloat16 Matrix Performance with Structured Sparsity2.3 PFLOPs
Transistor Count73 Billion
OS SupportLinux x86 64-Bit
External Power Connectors12V-2x6
Typical Board Power (TBP)600W
TBP (Max)600W
TBP configurable450W
GPU Memory Last Level Cache (LLC)128 MB
Dedicated Memory Size144 GB
Dedicated Memory TypeHBM3E
Infinity CacheYes
Memory Interface4096-bit
Peak Memory Bandwidth4 TB/s
Memory ECC SupportYes (Full-Chip)
Board Form FactorPCIe Add-in Card
Bus TypePCIe 5.0 x16
CoolingPassive
DimensionsFull Height, 10.5" (267 mm) length, Double Slot
Supported TechnologiesAMD CDNA 4 Architecture, 4th Gen AMD Infinity Architecture, AMD ROCm
RAS SupportYes
Page RetirementYes
Page AvoidanceYes
SR-IOVYes
Software API SupportOpenMP, OpenCL, HIP, ROCm Open Ecosystem
FrameworksTensorFlow, PyTorch, ONYX-RT, SGLang, JAX, Triton, Kokkos, RAJA

Frequently Asked Questions

What is the AMD Instinct MI350P?

The AMD Instinct MI350P is a PCIe accelerator card designed for efficient local AI inference pipelines in air-cooled data centers.

What architecture is the AMD Instinct MI350P based on?

The AMD Instinct MI350P is based on the CDNA 4 architecture.

How much memory does the AMD Instinct MI350P have?

The AMD Instinct MI350P has 144GB of HBM3E memory.

What is the peak performance of the AMD Instinct MI350P?

The AMD Instinct MI350P offers a peak performance of 4.6 PFLOPs for microscaling four-bit and six-bit precision matrix operations.

What is the default board power of the AMD Instinct MI350P?

The default board power of the AMD Instinct MI350P is 600W, with a configurable 450W mode.